What Is Papillex™

Papillex

Papillex™ is a clinically-researched, nutrient-rich supplement designed to optimize your body’s ability to respond to HPV. By optimizing your natural immunity and replacing missing and low nutrients, Papillex™ helps you to create an inhospitable environment for HPV to live.

Studies have demonstrated that through nutritional support, HPV symptoms such as genital warts, cervical dysplasia, and other HPV related conditions can be managed.

  • Relieve HPV discomfort
  • Respond to recurrent outbreaks
  • Support your body’s resilience and ability to respond

Why watch and wait, when you can be proactive?

Research and Ingredients

Papillex™ helps to support a normal immune system, correct nutritional deficiencies and improve the body’s immune response, enabling it to effectively respond to the HPV virus, regulating it as a part of the human microbiome. The Papillex™ formula combines a series of high potency ingredients that have been shown in multiple research studies to effectively combat HPV.

Our formulation contains high-quality, pure ingredients, sourced from North America. They are regularly tested to ensure they are free from chemicals and by-products exceeding FDA and Health Canada Standards for quality. The Papillex™ formula is contained within vegan capsules.

While eating a healthy diet can help you to improve your body’s response to HPV, research suggests that additional support using high potency clinically-proven nutrients can help support that response.

Papillex™ contains:

Papillex

Lycopene & Carotenoids

Studies have shown that those with low levels of carotenoids have an increased risk of persistent HPV infections.1 High levels of vegetable consumption have been shown to decrease HPV persistence by more than 50%.2 Higher levels of lycopene are associated with decreased risk of CIN 3 and cervical cancer.2 This shows the importance of loading up on richly-pigmented vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach and kale to support homeostasis and a healthy microbiome.

A daily serving of Papillex™ contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.

Science behind this*

  • Calculation: 8000IU x 2= 16000IU), 3mg of betacarotene is 5000 IU, need 9.6mg. Source
  • 1Peterson, Caryn E., et al. “Combined antioxidant carotenoids and the risk of persistent human papillomavirus infection.” Nutrition and cancer 62.6 (2010): 728-733. Source
  • 2Tomita LY, Filho AL, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA. Diet and serum micronutrients in relation to cervical neoplasia and cancer among low‐income Brazilian women. International journal of cancer. 2010 Feb 1;126(3):703-14. Source

Broccoli

Broccoli Sprout Extract

Indole-3-carbinol, DIM, and sulphoraphane are powerful metabolites found in broccoli family vegetables that support the body in the repair of DNA damage and have been shown to lower the risk of cancer.3,4,5 These important ingredients are found in: cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower and kale.

To garner the same benefit as a daily serving of Papillex™, you would need to eat 1 head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day.

Science behind this*

  • Calculation: 200mg*2 = 400mg. SourceSource
  • 3Higdon, Jane V., et al. “Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.” Pharmacological Research 55.3 (2007): 224-236. Source
  • 4Lenzi, Monia, Carmela Fimognari, and Patrizia Hrelia. “Sulforaphane as a promising molecule for fighting cancer.” Advances in Nutrition and Cancer. Springer Berlin Heidelberg, 2014. 207-223. Source
  • 5Li, Yanyan, and Tao Zhang. “Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.” Future Oncology 9.8 (2013): 1097-1103. Source

Spinach

Vitamin B9 Folate

A water-soluble B vitamin, studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression to cervical and oral cancer.6,7,8,9 Folate rich foods include: dark green leafy vegetables (such as: spinach, asparagus and Brussels sprouts), nuts and beans, and liver.

A daily serving of Papillex contains the equivalent of 5oz of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.

Science behind this*

  • Calculation (400mcg*2) 800mcg. Source
  • 6Bai, Li-Xia, et al. “Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.” Asian Pacific journal of cancer prevention: APJCP 15.21 (2013): 9313-9317. Source
  • 7Moody, Michael, et al. “Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.” Cancer cell international 12.1 (2012): 1. Source
  • 8Arthur, Anna E., et al. “Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis.” Nutrition and cancer 63.5 (2011): 734-742. Source
  • 9Paul, Proma, Haripriya Vedantham, and V. Keerti. “Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs).” International Journal of Women’s Health 2 (2010): 7-12. Source

Lemon

Vitamin C

A powerful antioxidant; research studies conclude that individuals with higher Vitamin C levels have a lower HPV viral load, and decreased frequency of the development of oral and cervical cancer.10,11,12 Foods highest in Vitamin C include: yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli.

A daily serving of Papillex™ contains the equivalent of 1/2 yellow pepper, 1 guavas or 2 cups of kale.

Science behind this*

  • Calculation: (70mg*2 = 140mg) Source
  • 10Nirmala, J. Grace, and R. T. Narendhirakannan. “Detection and genotyping of high-risk HPV and evaluation of anti-oxidant status in cervical carcinoma patients in Tamil Nadu State, India-a case control study.” Asian Pacific Journal of Cancer Prevention 12.10 (2011): 2689-2695. Source
  • 11Esquenazi, David, et al. “The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.” Brazilian journal of otorhinolaryngology 76.1 (2010): 78-84. Source
  • 12Chen, Alyce A., et al. “Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.” Carcinogenesis 30.6 (2009): 977-981. Source

Green Tea

Camelia sinensis

Green tea has long been known as a powerful anti-viral and anti-infective plant that stimulates the immune system13. Green tea is often used topically for genital warts and cervical dysplasia. Orally, green tea intake has been associated with slowed progression and decreased risk of cancer through its powerful antioxidant effects14.

A daily serving of Papillex™ contains the equivalent of 2.5 cups of green tea.

Science behind this*

  • Calculation: 300 mg of polyphenols. One cup of green tea = 140mg polyphenols. Source
  • 13Rosen, T. “Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications.” Journal of drugs in dermatology: JDD 11.11 (2012): e55-60. Source
  • 14Wang YQ, Lu JL, Liang YR, Li QS. Suppressive effects of egcg on cervical cancer. Molecules. 2018 Sep;23(9):2334. Source

Avocado

Vitamin E

Has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities.15 Foods high in Vitamin E include: cooked spinach, almonds, roasted sunflower seeds, avocados and fish.

A daily serving of Papillex™ contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados.

Science behind this*

  • Calculation: (60*2IU = 120IUs ): 1IU = 1 mg on average = 120mg Source Source
  • 15Kang, Tae Heung, et al. “Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.” PloS one 9.7 (2014): e103562. Source

Brazil Nut

Selenium

An essential trace mineral; individuals with cervical dysplasia have been reported to have low levels of selenium.16 In recent animal studies, selenium has also been shown to increase cell death in HPV infected cells.17 Selenium is a difficult nutrient to provide the body with, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include: brazil nuts, oysters, tuna and sunflower seeds.

A daily serving of Papillex™ contains the equivalent of 3 oysters, 4 ounces of tuna, or 3 brazil nuts.

Science behind this*

  • Calculation: 60mcg*2 = 120 mcg, 50mcg per brazil nut Source
  • 16Abulizi G, Zhang YY, Mijiti P, Li H, Abuduxikuer G, Cai J, Dong ZH, Naizhaer G, Yang XW, Maimaiti M, Abudurexiti G. Serum Se, Ni, and As are associated with HPV infection and CIN2+ among Uyghur women in rural China. BMC cancer. 2018 Dec;18(1):925. Source
  • 17Tolen, Jennifer A., et al. “Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro.” International journal of reproductive medicine 2015 (2015). Source

Astragalus

Astragalus

This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herbs impact on the growth of abnormal cervical epithelial cells; halting cell growth and reducing expression.18

Science behind this*

  • 18Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20. Source

Reishi Mushroom

Ganoderma lucidum

The Reishi mushroom has been celebrated for its antiviral properties for more than 2000 years. Clinical studies have shown that the use of these medicinal mushrooms has dramatically impacted the clearance rate of HPV, both vaginal and oral.19,20

Science behind this*

  • 19Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014). Source
  • 20Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014). Source

Healthy Lifestyle and Papillex Work Hand-In-Hand

Make these 5 lifestyle changes and get results faster!

Papillex

Eat plenty of fruits and vegetables – especially those rich in vitamin A and carotenoids. A recent study in the journal of Cancer Epidemiology, Biomarkers and Prevention found that women who consumed large amounts of vegetables were less likely to have persistent HPV. Getting your essential vitamins and minerals will keep your immune system strong.

Be nice to your immune system by leading a healthy lifestyle. Beyond dietary considerations and smoking cessation, you should be getting plenty of sleep, abstaining from recreational drugs and alcohol, and avoiding high amounts of stress. Many alternative health aficionados will use meditation or acupuncture, as they are stress relieving and cause the body to release chemicals beneficial to fighting disease.

Drink Green Tea. There is a growing body of evidence that suggests the flavonoid ECGC may inhibit the development of HPV warts and cervical lesions. It is currently undergoing studies for its effectiveness as an HPV treatment.

Papillex

Quit smoking. Smoking is detrimental to your health in countless ways; there really is no bodily system or vital organ that gets by unscathed by this habit. What’s more, according to a study published in the journal of Cancer Causes and Control, smoking doubles the risk of HPV progressing into cervical cancer.

Women should know that long-term use of oral contraceptives has been connected to an increased risk of developing cervical cancer. 99% of all cervical cancers are the result of the HPV virus; however, the Institute for Research on Cancer found that women who have the HPV virus and have used oral contraceptives for five years are nearly four times as likely to develop cervical cancer. The good news is that the risk decreases once women go off the pill.

Sweat every day! Exercise decreases stress hormones and can have an anti-inflammatory effect on your body. It also is a great way to improve circulation, making sure toxins are being released and nutrients make its way into your body.

Why watch and wait, when you can be proactive?

Papillex™ is a unique blend of ingredients that have powerful immune boosting properties, and have been shown to support natural relief of HPV.

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*we do not adopt any medical treatment claims that may be mentioned in the citations, as we refer to the scientific literature for a balanced view of the natural food sources of the nutrients