What Is Papillex® ?

Papillex® is an evidence-based supplement featuring nutrients and ingredients designed to support your immune system.* Papillex®replaces key nutrients that have been found to be missing and low in people with reduced immunity.

Evidence-based Ingredients

 The Papillex® formula combines a series of ingredients that have been shown in multiple research studies to support the immune system and cervical wellness.* While eating a healthy diet can help you support your body’s immune response, research suggests that supplementing with high-potency, evidence-based nutrients can help provide additional support.*

Papillex® Contains:

Here is a complete list of the ingredients contained in Papillex®:

Lycopene & Carotenoids

Studies have shown that those with deficient levels of carotenoids and lycopene need additional immune support.*(1) High levels of carotenoid-rich vegetable consumption has been shown to support overall health and cervical wellness.*(2) Higher levels of lycopene are associated with positive immune response benefits.*(2) Loading up on richly-pigmented vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach and kale help to support immunity*.

A daily serving of Papillex® has levels of naturally occurring carotenoids similar to 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.(1)

  • Calculation: 8000IU x 2= 16000IU), 3mg of betacarotene is 5000 IU, need 9.6mg. Source
  • 1Peterson, Caryn E., et al. “Combined antioxidant carotenoids and the risk of persistent human papillomavirus infection”. Nutrition and cancer 62.6 (2010): 728-733. Source
  • 2Tomita LY, Filho AL, Costa MC, Andreoli MA, Villa LL, Franco EL, Cardoso MA. “Diet and serum micronutrients in relation to cervical neoplasia”. International journal of cancer. 2010 Feb 1;126(3):703-14. Source

Broccoli Sprout Extract

Indole-3-carbinol, DIM, and sulforaphane are powerful metabolites found in broccoli family vegetables that support DNA health and have been shown to promote overall health and cervical wellness.*(3,4,5) These important ingredients are found in cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower and kale.

To garner a similar nutrient benefit as a daily serving of Papillex®, you would need to eat 1 head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day.

  • Calculation: 200mg*2 = 400mg. Source 1 Source 2
  • 3Higdon, Jane V., et al. “Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.” Pharmacological Research 55.3 (2007): 224-236. Source
  • 4Lenzi, Monia, Carmela Fimognari, and Patrizia Hrelia. “Sulforaphane as a promising molecule for fighting cancer.” Advances in Nutrition and Cancer. Springer Berlin Heidelberg, 2014. 207-223. Source
  • 5Li, Yanyan, and Tao Zhang. “Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.” Future Oncology 9.8 (2013): 1097-1103. Source

Folate

Folate (and its synthetic counterpart folic acid) is a water-soluble B vitamin. Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as an increased risk of progression. Folate rich foods include dark green leafy vegetables (such as spinach, asparagus and Brussels sprouts), nuts and beans, and liver.(6,7,8,9)

A daily serving of Papillex® has levels of Folate similar to 5oz of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.

  • Calculation (400mcg*2) 800mcg. Source
  • 6Bai, Li-Xia, et al. “Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.” Asian Pacific journal of cancer prevention: APJCP 15.21 (2013): 9313-9317. Source
  • 7Moody, Michael, et al. “Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.” Cancer cell international 12.1 (2012): 1. Source
  • 8Asemi Z, Vahedpoor Z, Jamilian M, et al. Effects of long-term folate supplementation on metabolic status and regression of cervical intraepithelial neoplasia: A randomized, double-blind, placebo-controlled trial. Nutrition 2016; 32 (6): 681-6.Source
  • 9Paul, Proma, Haripriya Vedantham, and V. Keerti. “Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs).” International Journal of Women’s Health 2 (2010): 7-12. Source

Vitamin C and Zinc

A powerful antioxidant; research studies conclude that individuals with higher Vitamin C and Zinc levels support the immune system and the body’s response to HPV.* (10,11,12) 

Foods highest in Vitamin C include yellow bell peppers, guavas, dark green vegetables (especially kale and turnip greens), kiwi and broccoli. It is important that those concerned with maintaining immune health get enough Vitamin C. For this reason, we have included it in the Papillex® formula.

A daily serving of Papillex® has levels of Vitamin C similar to 1/2 yellow pepper, 1 guava or 2 cups of kale.

  • Calculation: (70mg*2 = 140mg) Source
  • 10Nirmala, J. Grace, and R. T. Narendhirakannan. “Detection and genotyping of high-risk HPV and evaluation of anti-oxidant status in cervical carcinoma patients in Tamil Nadu State, India-a case control study.” Asian Pacific Journal of Cancer Prevention 12.10 (2011): 2689-2695. Source
  • 11Ayatollahi H, Rajabi E, Yekta Z, Jalali Z. “Efficacy of Oral Zinc Sulfate Supplementation on Clearance of Cervical Human Papillomavirus (HPV); A Randomized Controlled Clinical Trial”. Asian Pac J Cancer Prev. 2022 Apr 1;23(4). Source
  • 12Chen, Alyce A., et al. “Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.” Carcinogenesis 30.6 (2009): 977-981. Source

Camelia Sinensis

Camelia sinensis is a broad term for the types of shrubs and plants used to produce tea. Green tea has long been known as a powerful plant that stimulates the immune system.*(13) Green tea is used topically and orally. Orally, green tea intake has been associated with a positive impact on cervical and reproductive health through its antioxidant properties.*(14) 

A daily serving of Papillex® has antioxidant properties of 2.5 cups of green tea.

  • Calculation: 300 mg of polyphenols. One cup of green tea = 140mg polyphenols. Source
  • 13Rosen, T. “Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications.” Journal of drugs in dermatology: JDD 11.11 (2012): e55-60. Source
  • 14Wang YQ, Lu JL, Liang YR, Li QS. “Suppressive effects of EGCG on cervical cancer.” Molecules. 2018 Sep;23(9):2334. Source

Vitamin E

Vitamin E has been shown through clinical studies to promote cervical cell health and support the immune system through its powerful antioxidant properties.*(15) Foods high in Vitamin E include: cooked spinach, almonds, roasted sunflower seeds, avocados and fish.

A daily serving of Papillex® has levels of Vitamin E similar to 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados.

  • Calculation: (60*2IU = 120IUs ): 1IU = 1 mg on average = 120mg Source 1
  • 15Ono, A., Koshiyama, M., Nakagawa, M., Watanabe, Y., Ikuta, E., Seki, K., & Oowaki, M. (2020). “The Preventive Effect of Dietary Antioxidants on Cervical Cancer Development.” Medicina (Kaunas), 56(11), 604. Source

Selenium

Selenium is an essential trace mineral. Individuals with cervical dysplasia have been reported to have deficient levels of selenium.(16) In recent studies, selenium has also been shown to support cervical and cellular health.*(17)

Selenium is a difficult nutrient to obtain, as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include: brazil nuts, oysters, tuna and sunflower seeds.

  • Calculation: 60mcg*2 = 120 mcg, 50mcg per brazil nut Source
  • 16Karamali M, Nourgostar S, Zamani A, Vahedpoor Z, Asemi Z. “The favorable effects of long-term selenium supplementation on regression of cervical tissues and metabolic profiles of patients with cervical intraepithelial neoplasia: a randomised double-blind placebo controlled trial.” Br J Nutr. 2015 Dec 28;114(12):2039-45. Source

Astragalus

This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown the herb’s impact on the health of cervical epithelial cells, regulating cell growth.*(18)

17Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20. Source

Ganoderma Lucidum

The reishi mushroom has been celebrated for its properties for more than 2,000 years. Clinical studies have shown that the use of these mushrooms dramatically support the immune system.* (19,20)

  • 18Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014). Source
  • 19Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014). Source

Boost Up Your Papillex® with AHCC®

AHCC® and Papillex®
are natural partners, especially when it comes to supporting your immune health.*

Papillex® contains nutrients and phytochemicals that have been shown in research to support the body’s response to HPV.* Papillex® provides all of these commonly deficient nutrients in their most potent and bioavailable forms. 

While maintaining a healthy lifestyle and correcting nutrient deficiencies can help to support your body’s response to HPV, additional support using the appropriate dose of clinically-researched supplements like AHCC® by Papillex® can be greatly beneficial.

AHCC® is one of the best-researched nutritional supplements in the world, backed by over 30 clinical trials. It provides daily immune system support and works as a biological response modifier (BRM) to turn up the dial on your immune response.* Early phase clinical trial also shows a high clearance rate of HPV infection after 6 months of use.*

Together, Papillex® and AHCC® create a complementary effect in helping your body optimize its immune response.* Buy together through the link below and receive a 5% discount on your purchase.

Boost Up Your Papillex® with AHCC®

AHCC® and Papillex®
are natural partners, especially when it comes to supporting your immune health.*

Papillex® contains nutrients and phytochemicals that have been shown in research to support the body’s response to HPV.* Papillex® provides all of these commonly deficient nutrients in their most potent and bioavailable forms. 

While maintaining a healthy lifestyle and correcting nutrient deficiencies can help to support your body’s response to HPV, additional support using the appropriate dose of clinically-researched supplements like AHCC® by Papillex® can be greatly beneficial.

AHCC® is one of the best-researched nutritional supplements in the world, backed by over 30 clinical trials. It provides daily immune system support and works as a biological response modifier (BRM) to turn up the dial on your immune response.* Early phase clinical trial also shows a high clearance rate of HPV infection after 6 months of use.*

Together, Papillex® and AHCC® create a complementary effect in helping your body optimize its immune response.* Buy together through the link below and receive a 5% discount on your purchase.

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