What Is Papillex™

Papillex™

Papillex™ is a clinically researched, nutrient rich supplement designed to increase your body’s ability to fight HPV. By increasing your natural immunity and replacing missing and low nutrients, Papillex™ helps you to create an inhospitable environment for HPV to live.

Studies have demonstrated that through nutritional support, HPV symptoms such as genital warts, cervical dysplasia, and other HPV-related conditions have been eliminated.

  • Relieve HPV symptom discomfort
  • Reduce recurrent outbreaks
  • Improve your body’s resilience and ability to fight illness

Why watch and wait, when you can be proactive?

Research and Ingredients

Papillex™ helps to correct nutritional deficiencies and improve the body’s immune response, enabling it to fight the HPV virus. The Papillex™ formula combines a series of high dose ingredients that have been shown in multiple research studies to effectively combat HPV.

Our formulation contains high-quality, pure ingredients, sourced from North America. They are regularly tested to ensure they are free from chemicals and byproducts exceeding FDA and Health Canada Standards for quality. The Papillex™ formula is contained within vegan capsules.

While eating a healthy diet can help you to improve your body’s response to HPV, research suggests that additional support using high dose clinically-proven nutrients can help to reduce (and in many cases) diminish the active virus.

Papillex™ contains:

Papillex

Lycopene & Carotenoids

Studies have shown that those with low levels of carotenoids have an increased risk of persistent HPV infections.1 High levels of vegetable consumption have been shown to decrease HPV persistence by more than 50%.2 This shows the importance of loading up on richly pigmented vegetables such as peppers, tomatoes, carrots, mangos, sweet potatoes, spinach and kale.

A daily dose of Papillex™ contains the equivalent of 3/4 cup of frozen cooked spinach, 3 cups of raw carrots, or 2.5 cups of raw cantaloupe daily.

Science behind this

  • Calculation: 8000IU x 2= 16000IU), 3mg of betacarotene is 5000 IU, need 9.6mg. Source
  • 1Peterson, Caryn E., et al. “Combined antioxidant carotenoids and the risk of persistent human papillomavirus infection.” Nutrition and Cancer 62.6 (2010): 728-733. Source
  • 2Sedjo, Rebecca L., et al. “Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection.” Cancer Epidemiology Biomarkers & Prevention 11.9 (2002): 876-884. Source

Broccoli

Cruciferous Vegetables

Indole-3-carboniol and sulforaphane are two powerful metabolites that support the body in the repair of DNA damage and have been shown to lower the risk of cancer.3,4,5 These important ingredients are found in cabbage, broccoli, broccoli sprouts, Brussels sprouts, cauliflower and kale.

To garner the same benefit as a daily dose of Papillex™, you would need to eat 1 head of broccoli, 2 cups of Brussels sprouts, or 2.8 cups of raw cabbage per day.

Science behind this

  • Calculation: 200mg*2 = 400mg. SourceSource
  • 3Higdon, Jane V., et al. “Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.” Pharmacological Research 55.3 (2007): 224-236. Source
  • 4Lenzi, Monia, Carmela Fimognari, and Patrizia Hrelia. “Sulforaphane as a promising molecule for fighting cancer.” Advances in Nutrition and Cancer. Springer Berlin Heidelberg, 2014. 207-223. Source
  • 5Li, Yanyan, and Tao Zhang. “Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.” Future Oncology 9.8 (2013): 1097-1103. Source

Spinach

Vitamin B9 Folate

Studies have found that individuals with a folate deficiency have an increased risk of positive HPV status, as well as increased risk of progression to cervical and oral cancer.6,7,8,9 Folate-rich foods include dark green leafy vegetables like spinach, asparagus, brussel sprouts, nuts, beans, and liver.

A daily dose Papillex contains the equivalent of 5oz of poultry liver, 4 cups of chickpeas, or 40 spears of asparagus.

Science behind this

  • Calculation (400mcg*2) 800mcg. Source
  • 6Bai, Li-Xia, et al. “Folate deficiency and FHIT hypermethylation and HPV 16 infection promote cervical cancerization.” Asian Pacific journal of cancer prevention: APJCP 15.21 (2013): 9313-9317. Source
  • 7Moody, Michael, et al. “Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.” Cancer cell international 12.1 (2012): 1. Source
  • 8Arthur, Anna E., et al. “Higher micronutrient intake is associated with human papillomavirus-positive head and neck cancer: a case-only analysis.” Nutrition and cancer 63.5 (2011): 734-742. Source
  • 9Paul, Proma, Haripriya Vedantham, and V. Keerti. “Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR) types of human papillomaviruses (HPVs).” International Journal of Women’s Health 2 (2010): 7-12. Source

Lemon

Vitamin C

A powerful antioxidant; research studies conclude that individuals with higher vitamin C levels have a lower HPV viral load and decreased frequency in the development of oral and cervical cancer.10, 11,12 Foods highest in Vitamin C include yellow bell peppers, guavas, dark green vegetables (especially kale), turnip greens, kiwi and broccoli.

A daily dose of Papillex™ contains the equivalent of 1/2 yellow pepper, 1 guavas or 2 cups of kale.

Science behind this

  • Calculation: (70mg*2 = 140mg) Source
  • 10Nirmala, J. Grace, and R. T. Narendhirakannan. “Detection and genotyping of high-risk HPV and evaluation of anti-oxidant status in cervical carcinoma patients in Tamil Nadu State, India-a case-control study.” Asian Pacific Journal of Cancer Prevention 12.10 (2011): 2689-2695. Source
  • 11Esquenazi, David, et al. “The frequency of human papillomavirus findings in normal oral mucosa of healthy people by PCR.” Brazilian journal of otorhinolaryngology 76.1 (2010): 78-84. Source
  • 12Chen, Alyce A., et al. “Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.” Carcinogenesis 30.6 (2009): 977-981. Source

Green Tea

Camelia Sinensis

Green tea has long been known as a powerful anti-viral and anti-infective plant that stimulates the immune system13. Green tea is often used topically for genital warts and can be used topically in treatments of cervical dysplasia. Orally, green tea intake has been associated with decreased risk of cancer through its powerful antioxidant effects.

A daily dose of Papillex™ contains the equivalent of 2.5 cups of green tea.

Science behind this

  • Calculation: 300 mg of polyphenols. One cup of green tea = 120mg polyphenols. Source
  • 13Rosen, T. “Green tea catechins: biologic properties, proposed mechanisms of action, and clinical implications.” Journal of drugs in dermatology: JDD 11.11 (2012): e55-60. Source

Avocado

Vitamin E

Has been shown through clinical studies to inhibit cancer cell growth and support the immune system through its powerful antioxidant capabilities.14 Foods high in Vitamin E include cooked spinach, almonds, roasted sunflower seeds, avocados and fish.

A daily dose of Papillex™ contains the equivalent of 32 cups of cooked spinach, 3 cups of whole almonds, or 28 whole avocados.

Science behind this

  • Calculation: (60*2IU = 120IUs ): 1IU = 1 mg on average = 120mg Source Source
  • 14Kang, Tae Heung, et al. “Treatment of tumors with vitamin E suppresses myeloid derived suppressor cells and enhances CD8+ T cell-mediated antitumor effects.” PloS one 9.7 (2014): e103562. Source

Brazil Nut

Selenium

An essential trace mineral, individuals with cervical dysplasia have been reported to have low levels of selenium.15 In recent animal studies, selenium has also been shown to increase cell death in HPV infected cells.16 Selenium is a difficult nutrient to provide the body with as many of our soils are depleted of this essential mineral. Foods that are generally higher in selenium include brazil nuts, oysters, tuna and sunflower seeds.

A daily dose of Papillex™ contains the equivalent of 3 oysters, 4 ounces of tuna, or 3 brazil nuts.

Science behind this

  • Calculation: 60mcg*2 = 120 mcg, 50mcg per brazil nut Source
  • 15Cunzhi, Han, et al. “Serum and tissue levels of six trace elements and copper/zinc ratio in patients with cervical cancer and uterine myoma.” Biological trace element research 94.2 (2003): 113-122. Source
  • 16Tolen, Jennifer A., et al. “Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro.” International journal of reproductive medicine 2015 (2015). Source

Astragalus

Astragalus

This powerful immune modulator has been used for centuries to promote resilience in the body. Recent studies have shown that astragalus impacts the growth of cervical epithelial cells, stopping cell growth and reducing expression.17

Dosing differs depending on the source, so consult your naturopathic practitioner, or herbal compound before self-prescribing a dose.

Science behind this
  • 17Lyu, Ling, et al. “Effects of Astragalus injection on cervical immortalized epithelial cell growth and its cell cycle regulation mechanism.” Journal of Hainan Medical University 22.4 (2016): 17-20. Source

Reishi Mushroom

Ganoderma Lucidum

The Reishi mushroom has been celebrated for its antiviral properties for more than 2000 years. Clinical studies have shown that the use of these medicinal mushrooms have dramatically impacted the clearance rate of HPV both vaginal and oral.18, 19

As dosages vary depending on source and extraction method, we recommend consulting your naturopathic practitioner, or herbal compound before self-prescribing a dose.

Science behind this

  • 18Donatini, Bruno. “Control of Oral Human Papillomavirus (HPV) by Medicinal Mushrooms, Trametes versicolor and Ganoderma lucidum: A Preliminary Clinical Trial.” International journal of medicinal mushrooms 16.5 (2014). Source
  • 19 Hernandez-Marquez, Eva, et al. “Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes) on transformed cells by Human Papillomavirus.” International journal of medicinal mushrooms 16.2 (2014). Source

Healthy Lifestyle and Papillex Work Hand-In-Hand

Make these 5 lifestyle changes and get results faster

Papillex

Eat plenty of fruits and vegetables – especially those rich in vitamin A and carotenoids. A recent study in the journal Cancer Epidemiology, Biomarkers and Prevention found that women who consumed large amounts of vegetables were less likely to have persistent HPV. Getting your essential vitamins and minerals will keep your immune system strong.

Be nice to your immune system by leading a healthy lifestyle. Beyond dietary considerations and not smoking, you should be getting plenty of sleep, abstaining from recreational drugs and alcohol, and avoiding egregious amounts of stress. Many alternative health aficionados will use shiatsu or acupuncture, as they are stress relieving and cause the body to release chemicals beneficial to fighting disease.

Drink Green Tea. There is a growing body of evidence that suggests the flavonoid ECGC may inhibit the development of HPV warts and cervical lesions. It’s a potent anti-cancer elixir; especially the sencha or matcha varieties.

Papillex

Quit smoking. Smoking is detrimental to your health in countless ways; there really is no bodily system or vital organ that gets by unscathed by this habit. What’s more, according to a study published in the journal Cancer Causes and Control, smoking doubles the risk of HPV progressing into cervical cancer.

Women should know that long-term use of oral contraceptives has been connected to an increased risk of developing cervical cancer. 99% of all cervical cancers are the result of the HPV virus; however, the Institute for Research on Cancer found that women who have the HPV virus and have used oral contraceptives for five years are nearly four times as likely to develop cervical cancer. The good news is that the risk decreases once women go off the pill.

Why watch and wait, when you can be proactive?

Papillex™ is a clinically researched, nutrient rich supplement designed to increase your body’s ability to fight HPV.

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