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Frequently Asked Questions

Here are some frequently asked questions about PAPILLEX™ for HPV.

FAQ For Customers
FAQ For Retailers

FAQ For Customers


What is Papillex™?
Papillex™ is a phytoceutical complex formulated to treat HPV naturally. The

key ingredients in Papillex™ safely and effectively aid in the elimination

ofg enital warts, cervical dysplasia and other HPV related conditions.

Papillex™ can help you overcome symptoms of HPV, boost your immune system,

and restore your peace of mind.

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What should I do in addition to taking Papillex ™ to help relieve symptoms of HPV?
In addition to taking Papillex, supplementation with Vitamin C is recommended

for (1-3 grams daily) and a high quality multi-vitamin is optional.
Eat a whole foods diet high in fruits and vegetables. A diversity of

vegetables is necessary.
Minimize the ingestion of animal products and saturated fats that impair

immunity and contribute to inflammation in the body.
Do not smoke. Smoking has been associated with an increased risk of some HPV

symptoms, such as dysplasia. This may be due to tobacco’s ability to diminish

nutrient levels in the blood.

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Can I take Papillex™ with my other supplements or medications?
There are no known interactions with Papillex™ and any natural supplements.

If you are taking other medications, we advise you to consult with your

healthcare practitioner before taking this product.

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Is it safe to take Papillex™ daily for long term use?
Yes, Papillex™ is safe and recommended for long term use.

Should I take Papillex™ if I have HPV but am not showing any

symptoms?
Papillex™ supports normal immune system response to HPV related conditions

and can increase your resistance with ongoing use.

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Can I take Papillex™ for a few months and once my immune system is balanced,

stop taking it?
Papillex™ is considered a daily supplement and should be taken as long as you

want to aid and protect the immune system when concerned with HPV related

conditions.



Is there anyone who should NOT take Papillex™?
Recipients of foreign organs and tissues, including bone marrow and corneal

transplants, are cautioned not to take any immune-regulating nutritional

supplements. Therefore, Papillex™ is NOT recommended for transplant patients.

People with synthetic replacement/reconstruction will not be affected, e.g.

hip, knee, breast, or pacemaker. People with autoimmune diseases, such as

Crohn’s disease, multiple sclerosis or systemic lupus erythematosus shouldn’t

use Papillex™ unless recommended by a qualified healthcare practitioner.We

recommend consulting with your health care practitioner before beginning any

natural health care regime.

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Are there any cautions associated with taking Papillex™?
If you are pregnant, nursing, a diabetic, an organ transplant recipient or

have multiple sclerosis, do not use unless on the advice of and under the

direct supervision of a health care professional.

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How long before I might expect to see some results?
As with many natural supplements, it can take a period of time before you

notice an improvement in your health. Although some people notice a

difference sooner, we suggest that you take Papillex™ for three months before

evaluating whether it is effective for you.

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How long does it take for cervical cancer to develop?
It is difficult to know how long it takes to develop cervical cancer. Women

with normal Pap smears can already be infected by HPV. If they are already

infected and the immune system is not checking the virus, women are then at

risk of developing precancerous lesions such as high grade lesion of the

cervix then cancer. We know that most but not all women with high grade

lesions will develop cervical cancer if they are not treated. But there is a

long interval between being infected, the development of high grade lesion

and eventually cancer giving many opportunities before full development of

cancer. In USA the estimated peaks of age for different stages of the disease

are:
.21 years for HPV infection
.28 years for low grade lesion (LSIL) of the cervix
.42 years for high grade lesion (HSIL) of the cervix and
.48 years for infiltrative cancer.

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Can you get HPV through oral sex?
Yes, HPV spreads through oral sex. We do not have all the facts about what

happens if someone gets HPV through oral sex. It is also not clear if HPV

spreads more easily when it goes from an infected person’s mouth to a

partner’s genitals, or from an infected person’s genitals to a partner’s

mouth. We know that HPV is linked to diseases in the mouth, the lungs, and

the digestive tract.

One type of HPV, known as HPV 16, is found in cancers of the tonsils, vocal

cords, the base of the tongue, the lungs and even the esophagus. This is a

high risk HPV because it may cause these kinds of cancers.

Low risk HPV, which causes genital warts, may be found in rare cases of

cancer of the vocal cords, and in growths in the mouth or the vocal cords.

This type of HPV can be destroyed by cold, heat, or laser.

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Is there a test to detect HPV?
A human papillomavirus (HPV) test is done to find a high-risk HPV infection

in women. HPV is a sexually transmitted disease (STD). An HPV test checks for

the genetic material (DNA) of the human papillomavirus. Like a Pap test, an

HPV test is done on a sample of cells collected from the cervix.
There are many types of HPV. Some types cause warts that you can see or feel.

Other types do not cause any symptoms. Most people do not know they have an

HPV infection.
This test will identify whether a high-risk type of HPV is present. In women,

high-risk types of HPV (such as types 16, 18, 31, and 45) cause changes in

the cells of the cervix that can be seen as abnormal changes on a Pap test.

Abnormal cervical cell changes may resolve on their own without treatment.

But some untreated cervical cell changes can progress to serious

abnormalities and may lead to cervical cancer over time if it is not treated.
Although HPV is found in both men and women, this test is not used on men.

Also, your doctor can usually diagnose visible genital warts with a physical

exam, so this test is not used to diagnose genital warts caused by low-risk

types of HPV.

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What exactly does the HPV test detect ?
There are tests to detect some strains of HPV, but these tests are not

publicly available. One test is used to detect high-risk HPV among women with

abnormal smear results to screen for cervical cancer, but even in those cases

the test may not be easily accessible.

Most of these tests are designed to detect the virus’ nucleic acids, the tiny

DNA molecules that contain genetic information. One available test is called

Hybrid Capture II. There are two different types of Hybrid Capture II tests.

One of these is only used for research purposes to detect low-risk HPV, those

types not related to cervical cancer. The other test is for high-risk HPV,

those types related to cervical cancer. When it is positive, it means that

you are a carrier of at least one of 13 high-risk types of HPV that are

detected by the test. It does not tell us which one or the number of

different strains that are present.

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What can you do to protect yourself from HPV?
Anyone who is sexually active is at risk for HPV. Since not all HPV

infections have symptoms, you may not be able to tell if you (or your

partner) is infected. Condoms are a good way to protect yourself from many

kinds of sexually transmitted infections. Use them consistently. But when it

comes to HPV, a condom can reduce the risk of transmitting the virus, but

doesn’t provide full protection. You can still get HPV from skin not covered

by the condom. Vaccination against HPV may not be 100 per cent effective at

preventing cancer and genital warts from the HPV types covered by the

quadrivalent vaccine. It won’t cure an existing HPV infection but it may

prevent other types of HPV covered by the vaccine. The best defense against

cancer of the cervix is regular Pap testing. Even if you have been vaccinated

against HPV, you should still have a Pap test within three years of becoming

sexually active. Then, you should have regular Pap tests as often as your

doctor suggests.

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After you get HPV, will it go away? Or will you have it forever?
A healthy immune system for most people will eventually develop protection

against the virus, preventing HPV from leaving the cell and creating lesions,

or transmitting the infection to babies or partners. Most people that get an

HPV infection will have it for life, in a latent state. Even after years of

successful treatment, a wart or a precancer or a cancer may reappear because

of a waning immune response such as what happens in pregnancy (immune

tolerance), in treatment of cancers or after a graft or in the case of AIDS

or HIV infection (immune deficiency) or when we get old (immunosenescence).

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Can men get HPV too?
Of course they can. And they are responsible for the major part of infection

to women and vice-versa. Men can develop external genital warts, precancer or

cancer of the penis and anus. Also they can develop cancers or warts in the

mouth or respiratory and digestive trees, as is the case with women.

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What are genital warts and why should I worry about them? Won’t they just go
away by themselves?
The viruses causing warts are usually types 6 and 11. They are associated

with chronic warty lesions of the anus and genital area. They are not

dangerous usually. But they may lead to lesions in the respiratory tract of

the baby when infected mothers deliver their baby through the vagina. Also

they are a common lesion on the vocal cords of adults probably acquired by

oral sex. In some women, these lesions are associated with abnormal Pap

smears and precancerous lesions of the outer portion of the genitalia. In

both sexes, they are associated with precancerous lesions of the anal area.

Their treatments are painful and may lead to scarring and pain with sex, even

many years after the treatment. The warts are associated with anxiety, fear

of cancer, depression, guilt, shame and loss of sexual interest.

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How are genital warts treated?
In general, treatment for genital warts caused by HPV is aimed at making the

immune system stronger so it can fight the HPV virus, or destroying the sores

or warts that HPV may cause. Papillex is formulated to strengthen and support

the immune system so that the body can naturally rid itself of genital warts.

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What causes cancer of the cervix?
High risk HPV appears to be a cause of cervical cancer. But many women who

have high risk HPV will not get cervical cancer.

There are two kinds of cervical cancer:

* One kind affects the skin surface of the cervix (squamous cell

carcinoma)
* The second kind affects the glands inside the cervix

(adenocarcinoma).

Cancer of the cervix occurs because you have been affected by a virus (such

as HPV), or because of other factors (known as human factors).

Viral Factors

* High risk HPV: HPV types 16 and 18 are known as high risk HPV.

As well, 11 other types of HPV put women at high risk for cervical cancer.
* Length of time: The high risk HPV needs to be in your body for

a long time before abnormal cells will increase.
* Integration: The high risk HPV needs to become part of the human

genetic code. When this happens, our body cannot protect us from developing

cancer.

Human Factors

* Genetics: some women are more likely to get cancer than others

(family history).
* Pregnancy: women who have had many babies are more at risk of

developing cervical cancer.
* Nutrition: not enough vitamin A can enhance the virus’ ability

to create cancer.
* Smoking: tobacco is a factor in causing many types of cancer,

including cervical cancer.
* Other STIs: HIV infection, genital herpes and chlamydia

enhance the risk that HPV may create cancer.
* Age at first intercourse: when a woman has sexual intercourse

at a young age, she is more likely to develop cervical cancer.
* Having Pap tests: Some women may not like Pap tests, but these

tests save lives. Not having regular Pap tests increases a woman’s risk for

cervical cancer.
* Hormone therapy: Taking birth control pills or hormone

replacement therapy may increase the risk slightly. For women who take birth

control pills, the risk of cervical cancer is deemed equal to that of

unwanted pregnancy. Women should not stop taking the pill to prevent cervical

cancer.

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Are there other causes of cervical cancer besides HPV?
Yes, but they are very rare. Most cancers of the cervix are associated with

HPV. Rare cancers of the cervix are types of cancer that screening tests

cannot find early or prevent. They include cancer of the skin (melanoma) that

has spread to the cervix and cancers of the muscles, nerves, and connective

tissues of the cervix. The other factors are listed in the previous question.

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How do you get HPV?
HPV is usually transmitted through intimate sexual contact between partners.

This may happen with rubbing the penis on the entrance of the vagina or the

anus, or kissing the genitals or anus of a partner. You do not need

penetration to transmit the infection. Some people wrongly think that not

ejaculating in the vagina protects them from acquiring an STI. It is not the

case. There are sufficient viruses for HPV transmission even when minimal

skin-to-skin contact occurs. Condoms should be worn for partial protection

from the start of intercourse until the end.

HPV can also be transmitted during delivery from the infected mother to the

baby. Most of the time, mothers do not even know they are infected.

HPV can also be transmitted by sharing contaminated sex toys. Sex toys are to

be used by one partner at a time. Sharing sex toys without properly

disinfecting them carries a risk of transmission for all STIs. If sex toys

are to be shared they can be used with condoms, as long as the condom is

changed each time a different partner uses the toy.

HPV cannot be passed by sitting on toilet seats or touching door knobs.


What is cervical dysplasia and what is the connection to HPV?
Cervical dysplasia is the abnormal growth of cells on the surface of the

cervix. Although this is not cancer, this is considered a precancerous

condition.
Cervical dysplasia is grouped into three categories:
.CIN I — mild dysplasia (a few cells are abnormal)
.CIN II — moderate to marked dysplasia
.CIN III — severe dysplasia to carcinoma-in-situ (precancerous cells

only in the top layer of the cervix)
Eighty to ninety percent of women with cervical dysplasia have an HPV

infection. Women with HPV have a greater chance of developing cervical

dysplasia.
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Does Papillex™ have any side effects?
When the immune system becomes balanced, some sensitive individuals may

experience reactions that indicate the body is trying to rid itself of

toxins. These reactions are temporary and uncommon, and may include digestive

problems, rashes, headaches and fatigue.

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Returns – We are truly determined to getting you well. Are you determined to

get well?
Our mission is fulfilled only after you have moved from disease to ease. We

hope to get you to this point.

In some cases, our customers may feel that the product has not produced all

the desired results, or that the healing was only partial. Please remember

that we go after the root-causes of the ailment, and this takes longer than

merely treating or suppressing symptoms. We request users to continue on the

protocol for a minimum of 2 months, and to contact us to discuss specific

issues. Given our commitment to helping you feel better we do not accept any

open returns until you have taken the therapy daily for 2 months.

In very rare cases, some remedies can create a healing-crisis (for e.g: acne

may get flared up for a day or two before starting to subside). Rapid viral

die-off and detox reactions also may occur in very rare cases with headache

or low-grade fever. In such cases, customers are advised to reduce the dose

to 50% of the recommended amount, and to slowly increase the dosage over a

period of 3 weeks, as the body needs to adapt to the changes. Please adapt

the dose recommendations to whatever you feel comfortable with.

We are extremely confident that at least one of our remedies will have you

feeling 100% better. If this is not the case, please do e-mail us at:

customerservice@papillex.com.

If you, for whatever reason, decide not to continue with our products, we

will honor all returns made after 2 months of use and within 3 months. But,

please take note that some chronic cases require a course beyond 2-3 months,

in order to completely heal.

Please send all returns to the address below. Contact us before sending for a

package code. Please include your name, order number, and credit card details

for the refund.

The address for returns is:
1835 Ferry Rd
Naperville, IL 60563, United States

Please note that the maximum possible return is $99 per customer.

Note: Returns cannot be accepted for orders that were discounted past the

sales price. Shipping charges are non-refundable.

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How should I take Papillex™?
Take two capsules daily, OR two capsules twice daily during acute outbreaks.

For best results, take with water or juice between meals on an empty stomach.

For those with difficulty swallowing, the capsule can be opened and the

contents mixed with applesauce or other fruit juice.

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Are there natural treatments for severe dysplasia ?
For severe dysplasia, in addition to Supplementation, cervical escharotic

therapy is a natural option. This procedure involves the application of

bromelain directly to the cervix, followed by a solution of zinc chloride and

Sanguinaria canadensis (bloodroot). Sanguinaria has a history of use as an

anti-cancer herb and may alter neovascularization, the process whereby a

growing tumor increases its blood supply. Washing the cervix with a calendula

solution and applying an herbal compound of thuja, echinacea, goldenseal, and

ligusticum finishes the escharotic procedure. Vaginal suppositories are also

utilized. Escharotic therapy should be performed twice per week for 10 weeks,

after which time another Pap smear and/or biopsy should be conducted. This

procedule can be done by a naturopathic physician specialized in this

treatment .

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I have heard that no silver bullet cure exists for HPV. Is there an HPV cure

?
While it is true that there is no HPV cure, Papillex™ works by helping your

body to heal itself naturally, and is formulated based on Groundbreaking

medical research.

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FAQ For Retailers

Who do I contact if I have general questions regarding the product?
Please e-mail customer service at customerservice@papillex.com or leave a

message at (647) 229 – 7279 and we will return your call

shortly.

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How do I place an order?
If you are an existing customer, you may place an order by logging into your

online account from our website,www.papillex.com., using your Customer ID and

password, and following the required steps to submit an order. If you are a

new customer, you must first register for an account prior to placing your

first order. This may be done by clicking on the “Retailer Home” link in the

upper right corner of our website, www.papillex.com, and registering for an

account. You will receive an e-mail providing a link to confirm your

registration. Click on the link to confirm and complete your registration.

You may also register by completing the Registration Form provided in the

sales package you received and faxing it to (416) 946 – 1774

.

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How do I register as a retailer?
You may register as a retailer in two ways. To register online, click on the

“Retailer Home” link in the upper right corner of our website,

www.papillex.com, and submit your company information. You will receive an

e-mail providing a link to confirm your registration. Click on the link to

confirm and complete your registration. You may also register by completing

the Registration Form provided in the sales package you received and faxing

it to (416) 946 – 1774 .


Why should I register as a retailer?
Once you register as a retailer, you will be able to purchase Papillex™ at

the wholesale price.

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How do I receive a sales package?
Contact Papillex™ sales representative, Vanessa Benlolo via e-mail at

Vanessa@papillex.com and request a sales package. Be sure to include your

name, your company name, mailing address, and phone number.


What does a start-up package of Papillex™ include?
A start-up package of Papillex™ includes 6 bottles (60 capsules each) of

Papillex™, Free Promotional Advertisement Offer, 15 Papillex™ Product

Brochures, 15 Customer FAQ Leaflets, 15 Ingredient Research Study Leaflets.

If, in the future, you require more copies of any of the above mentioned

promotional materials, please contact customer service at

customerservice@papillex.com and make a written request indicating the

quantities and products you need and we will send them to you free of charge

with your next shipment.

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How do I receive free advertisement?
In order to receive free advertisement, place a minimum order of 6 bottles of

Papillex™ and complete the “FREE Promotional Advertisement Agreement” form

before September 9th, 2009 and take advantage of this offer at no cost to

you!

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Where will our store be advertised?
Your store will be advertised only in the means you specify on the “FREE

Promotional Advertisement Agreement” form. You have the option of having your

store name advertised in our print ad campaign all across Toronto, or your

store name and location advertised on our website, or both. It is up to you,

but only if you place an order of at least 6 Papillex bottles before

September 9th, 2009.

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How do I know Papillex™ is a high quality product?
Papillex™ is a high quality product because it is made of the finest grade

ingredients that are scientifically proven to aid in the treatment of HPV and

is manufactured in a cGMP certified manufacturing facility. You can rest

assured that Papillex™ is effective, safe, and natural.

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Why is it so important that Papillex™ is manufactured in a cGMP certified
facility?
GMP stands for “Good Manufacturing Practices” and refers to the standards set

by the United States Food and Drug Administration, more commonly known as the

FDA. GMP regulations require that the processes by which products are made,

as well as the products themselves, are effective, safe, and pure. GMP

regulations also require that the manufacturers take care to avoid

contamination, errors, and mix-ups. All of these regulations ensure that the

customer gets a product that is what they want to buy and is not dangerous.

GMP is also often referred to as “cGMP,” which simply stands for “current

Good Manufacturing Practices.” Although not necessary when referring to GMP

certification, the “current” references GMP’s requirement that manufacturers

be up-to-date with their practices and procedures. GMP regulations even

control the training of employees, ensuring that not only is the technology

current, but the employees are knowledgeable and up-to-date on industry

practices and information. If a manufacturer is regulated by the FDA and

found to be in compliance with all GMP regulations, they are referred to as

GMP certified or cGMP certified. When choosing a supplement manufacturer, it

is absolutely essential that you select one that is cGMP certified. This

means that they are in compliance with all the GMP regulations, and you can

be sure that they are a reputable company that will provide a high-quality

product.

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What promotional products does Papillex™ provide to retailers?
Papillex™ provides Product Brochures, Ingredient Research Study Leaflets,

Customer FAQ Leaflets, and Bottle Information Pamphlets.

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Who do I contact in case I run out of Papillex™ promotional products?
Please contact customer service at customerservice@papillex.com and provide

your customer ID along with the amount and type of promotional products you

would like shipped to the address you have on file. If you would like the

promotional products shipped to a different address than the one we have on

file, please indicate this in your e-mail.

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Does Papillex™ provide training and seminars to retailers and their staff?
Papillex™ provides reading material, such as brochures, research studies, and

answers to frequently asked questions regarding the product, its ingredients,

and HPV in general, in print and available on our website, www. Papillex.com.

Although, we do not currently provide training and seminars to retailers and

their staff, we hope to provide this in the future. Please feel free to send

an e-mail to customer service at customerservice@papillex.com with any

questions you may have.