HPV virus is a non-enveloped DNA virus. It contains a circular, super-coiled, double-stranded DNA and an icosahedral nucleocapsid. It belongs to the papovaviridae family of viruses. About 100 types of the virus have been identified and these are further divided into low-risk strains and high-risk strains. Each type is believed to cause a different clinical entity. For example, skin warts are caused by HPV-1 to HPV-4. Types HPV-6 and HPV-11 are the main cause of common and genital warts. Types 16 and 18 are associated with cervical carcinoma.
Carcinogenesis by the HPV virus involves two proteins encoded by HPV genes, E6 and E7. These proteins interfere with the activities of the proteins encoded by tumor suppressor genes. The gene E6 inhibits the activity of p53 while E7 interferes with the activity of the Rb (retinoblastoma) gene. P53 and Rb genes are present in normal cells and their function is to suppress the cells that can produce tumors in the body. E6 and E7 inhibit the function of these tumor suppressor genes.
The diseases caused by the HPV virus are:
- Genital warts
- Common warts
- Plantar warts
- Laryngeal papillomas
- Facial warts
- Precancerous lesions of cervix, anus, penis, vulva, or uterus
- Cervical cancer
- Penile carcinoma in men
HPV virus is transmitted mainly through skin-to-skin contact and intimate sexual contact. It can also be transmitted to a neonate from an infected mother during delivery.
HPV virus related disorders can be fought by a healthy immune system. An immune system is the first line of defense against all diseases. Papillex is a compound that contains phytoceutical nutrients which have been shown to support beneficial outcomes. The ingredients in Papillex were chosen for their immune boosting properties.